Illumina

Sr Director/ Sr Principal Scientist, Protein Engineering

US - California - San Diego Full time
What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Position Summary:

Illumina is a global leader in genomics, dedicated to advancing healthcare through continuous innovation. We are seeking a visionary leader to join our Advanced Sciences department in the area of protein engineering. Depending on experience, career aspirations, and business needs, candidates may be considered for either the Sr Director or Sr Principal Scientist role.

This role offers the opportunity to shape the future of genomics and multiomics applications, lead cutting-edge research, and collaborate across disciplines. The successful candidate will provide strategic and technical leadership for the Protein Engineering function, influencing technology roadmaps and driving the development of innovative products. The Sr Director will additionally manage the Protein Engineering function in the US.

At Illumina, we value diversity. We encourage candidates of all backgrounds and experiences to apply, including those who may not meet every requirement but are excited about the opportunity to contribute to our mission and can provide a competitive advantage in other aspects of the role.

Responsibilities:

  • Shape and communicate the strategic vision for the protein engineering group, leading teams to execute on that vision.

  • Evaluate product needs in the marketplace and provide strategic research direction for protein/enzyme improvements to enhance existing and novel products.

  • Analyze internal and external assay capabilities to help create a market-leading product portfolio.

  • Develop strategies to ensure effective and efficient achievement of company objectives for genomics and multiomics markets as they pertain to protein engineering.

  • Translate strategy into executable operating plans, collaborating with peers across the organization to align and execute on strategic roadmaps.

  • Establish cross-department and cross-functional collaborations to ensure project and program needs are met by the protein engineering team.

  • Lead technology research and development teams in a highly matrixed organization.

  • Manage and/or influence program and project leaders to ensure progress on multiple projects and programs remains on track.

  • Develop and manage budgets for large capital expenditures and labor costs.

  • Maintain a comprehensive understanding of NGS workflows, from sample acquisition to data analysis.

  • Understand molecular details of NGS systems, including library preparation and sequencing chemistry.

  • Write and review publications (e.g., marketing collateral, scientific papers) and present to the Illumina executive team, board of directors, and at scientific conferences.

Listed responsibilities are not an exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs

Requirements: 

  • Expertise in the latest protein engineering techniques and methods; familiarity with DNA polymerases, transposases, reverse transcriptases, nanopores and other nucleic acid binding or modifying enzymes.

  • Demonstrated leadership skills with a track record of developing and mentoring senior leaders and individual contributors in diverse contexts.

  • Deep knowledge of Next Generation Sequencing (NGS) and hands-on experience with library preparation for Illumina sequencing systems or other sequencing technologies.

  • Experience in taking conceptual research through development to a viable product for commercialization.

  • Strong program and project management skills, including scope, scheduling, budget, and resource management.

  • Excellent presentation skills for diverse audiences.

All listed requirements are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional task and responsibilities.

Experience/Education:

  • PhD in Biological Sciences, Chemical Biology or equivalent experience.

  • Typically requires a Bachelor’s degree and a minimum of 20 years of related experience, with 12+ years of Management experience.

  • Experience managing and mentoring senior-level PhD scientists across various disciplines while overseeing product development projects.

  • Broad knowledge of all areas within protein engineering.

  • Deep technical knowledge in a variety of functions, gained from experience in both non-management and management roles.

If you are passionate about advancing science and technology, and excited to contribute to Illumina’s mission, we encourage you to apply, even if your experience doesn’t precisely match every requirement. We look forward to learning how your unique background and perspective can help us unlock the power of the genome.

The estimated base salary range for the Sr Director/ Sr Principal Scientist, Protein Engineering role based in the United States of America is: $220,500 - $330,700. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.


We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.