At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.
Job Description
At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfill their aspirations. Join Gilead and help create possible, together.
At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers.
We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Scientist, Analytical Operations, at Gilead you will ...
Develop and optimize N-glycan analysis workflows (HILIC-FLD, LC-MS, CE-LIF etc.), including sialic acid, NGNA, α‑Gal characterization and quantitation analysis.
Drive advanced structural elucidation of N-glycans using LC‑MS/MS, exoglycosidase sequencing, linkage analysis, monosaccharide analysis, and orthogonal structural tools.
Perform intact and subunit mass spectrometry, as well as glycopeptide mapping, to define glycan occupancy, site-specific heterogeneity, and structural impacts on the protein backbone.
Integrate glycan structural information with functional outcomes such as Fc receptor binding, Fc silencing/attenuation, CH2 stability, higher-order structure changes, aggregation, and immunogenicity risk.
Support glycosylation pCQA/CQA assessments, providing mechanism interpretation, structure-function justifications, and cross-program scientific guidance.
Support glycan-driven structural differences assessment in comparability studies.
Author technical reports, glycan characterization summaries, method development documentation, and regulatory submission content.
Continuously evaluate and implement emerging innovations in glycomics, glycoproteomics, and computational structure–function modeling.
At a future date, this position will relocate from Oceanside CA to the Gilead corporate HQ in Foster City, CA or will be hired directly to Foster City CA.
Basic Qualifications
BS with +6 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field OR
MS with +4 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field OR
PhD with 0 years of relevant experience in Analytical Chemistry, Glycobiology, Biochemistry, Biophysics, or related field.
Hands-on experience with LC‑MS or MS/MS for glycan or glycoprotein structural characterization.
Strong analytical reasoning and the ability to interpret complex structure–function relationships.
Excellent communication skills and ability to work effectively in a cross-functional, matrixed environment.
Preferred Qualifications
Deep expertise in glycan structural elucidation (MS/MS fragmentation, linkage analysis, exoglycosidase workflows).
Experience linking glycan features to biological activity: FcγR binding, effector function modulation, CH2/HOS stability, aggregation, or PK.
Proficiency with intact/subunit MS, peptide mapping, CE-SDS, SEC-MALS, cIEF and UPLC/HPLC techniques.
Knowledge of therapeutic antibody glycosylation, Fc engineering strategies, and effector-function silencing frameworks.
Familiarity with ICH Q5E/Q6B and analytical method qualification for glycan assays.
Experience with MS analysis tools (Protein Metrics, Peaks etc.) and analytics platforms (JMP etc.).
People Leader Accountabilities:
Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams.
Develop Talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop and realize their purpose.
Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.
The salary range for this position is:
Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.
For additional benefits information, visit:
https://www.gilead.com/careers/compensation-benefits-and-wellbeing
* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.
Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.
For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.
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Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.
Please apply via the Internal Career Opportunities portal in Workday.