Vice President, Programs and Portfolio Office(PPO)

The Vice President, Programs and Portfolio Office (PPO) will play a critical leadership role in driving strategic alignment, operational excellence, and execution discipline across MindMed’s portfolio of clinical and research programs. This individual will oversee the integrated program management function and ensure that portfolio decisions are data-driven, risk-aware, and aligned with corporate goals. 

As a member of the R&D leadership team, the VP, PPO will partner closely with the CEO, CMO, CFO, asset strategy leads, and functional heads to set priorities, track and anticipate resource allocation, and guide teams toward successful outcomes across all stages of development. 

Key Responsibilities 

• Strategic Portfolio Leadership 

• Lead portfolio planning and prioritization to align R&D investments with corporate strategy and value creation 

• Oversee governance processes, including portfolio reviews and decision-making forums 

• Develop frameworks for scenario planning, risk management, and budget optimization 

• Program Management Excellence 

• Build and lead a high-performing program management team responsible for the planning, coordination, and execution of all development programs (preclinical through late-stage) 

• Ensure cross-functional alignment, transparency, and accountability across clinical, regulatory, CMC, and commercial readiness functions 

• Oversee integrated project plans, timelines, milestones, and budgets 

• Interface with key external partners to integrate external project management with our internal cross-functional teams 

• Operational and Organizational Leadership 

• Establish best practices, tools, and templates for program governance, reporting, and performance tracking 

• Serve as a key interface between scientific/clinical teams and executive leadership to ensure timely, informed decision-making 

• Drive continuous improvement and a culture of collaboration, agility, and excellence 

• Executive and Board Engagement 

• Provide regular program and portfolio updates to executive leadership and the Board of Directors 

• Partner with Finance and Strategy functions on long-range planning and external communications 

Qualifications 

• Advanced degree in life sciences, medicine, or related field (Ph.D., Pharm.D., or M.S.) strongly preferred 

• 15+ years of experience in biotechnology or pharmaceutical program and portfolio management, including leadership of late-stage clinical programs 

• Proven track record in leading cross-functional development teams and managing complex program portfolios 

• Deep understanding of the drug development process, from IND through NDA and commercialization 

• Exceptional strategic thinking, analytical, and communication skills 

• Ability to thrive in a dynamic, fast-growing environment where hands-on leadership is required 

The starting base pay range for this position is $271,021.00 - $330,000.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:

• 100% paid health benefits including Medical, Dental and Vision for you and your dependents
• 401(k) program with company match and immediate vesting
• Flexible time off
• Generous parental leave and some fun fringe perks!