Senior Scientist Medicinal Chemistry

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients. 

About the role
Argenx is establishing a new department dedicated to small molecule and peptide drug discovery. We are seeking a Senior Scientist in Medicinal Chemistry to play a pivotal role in shaping this capability and advancing preclinical projects. This position offers the opportunity to influence strategy, drive innovation, and deliver high-quality drug candidates that make a real impact.

This position is based at our facility in Zwijnaarde (Ghent), and expects on-site presence.

Key Responsibilities

• Lead Discovery Projects: Partner with lead biologists to progress programs from hit identification through to clinical candidate nomination, ensuring timely delivery of high-quality candidates.
• Design and Optimise Molecules: Collaborate with CROs and expert consultants to design novel compounds addressing identified challenges and improving candidate profiles.
• Cross-Functional Collaboration: Work closely with internal experts in computational chemistry, ADME/Tox, IP, CMC, and pharmacology to integrate multidisciplinary insights.
• Innovation & Technology: Stay at the forefront of developments in small molecule and peptide therapeutics. Champion the use of AI, machine learning, and in silico approaches to accelerate design–make–test–analyse cycles.
• Data Management: Establish efficient workflows for capturing, integrating, and analysing data from multiple partners.
• Communication: Provide clear updates on progress, challenges, and solutions to stakeholders and project teams.
   

Profile

• PhD (or equivalent) in a relevant chemical science, with 8+ years of experience in biotech or pharma.
• Proven track record in design and synthesis of small molecules, with experience advancing projects to preclinical development.
• Ability to work independently and collaboratively within a team.
• Excellent communication skills, capable of presenting complex scientific concepts to diverse audiences.
• Fluent in written and spoken English to ensure clear and effective information exchange.  
• Demonstrated ability to take initiative and address challenges proactively.
• Dynamic and practical problem-solving approach with a focus on delivering tangible results.
   

Offer

• The opportunity to establish a new role within the organization, contributing to shaping its future direction.
• A competitive salary package accompanied by comprehensive benefits.
• Working in a human-sized, dynamic, rapidly growing biotech company, providing an engaging work environment.
   

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At argenx, all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer.

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