Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing.
The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today’s demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes. This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028.
Are you a problem-solver and change-agent who thrives in a Team environment, eager to tackle the most complex manufacturing challenges? If so, this is a once-in-a-lifetime opportunity to launch a state-of-the-art facility from the ground-up and shape the culture of our organization for the next generation.
Join us in Holly Springs, where you won't just build a plant—you will build the future of medicine.
The Opportunity:
This is an exciting opportunity to establish the North-Star standard for Operational Excellence for Roche/Genentech’s High Volume CVRM portfolio in Holly Springs.
The Head of Operational Excellence will drive Operational Excellence and Transformation into the design and start-up of the new Holly Springs site to deliver On-time start up, with high-throughput at optimal product cost and efficiency. This role will design-in and optimize the end-to-end product flow and cycle-time of medicines through the plant, using a blend of Lean, Operational Excellence tools with newest generation Industry 4.0 technology.
The role will also manage the plant Business Intelligence strategy, ensuring the IT/OT infrastructure and business systems deliver optimal analytics and intelligence to enable clear, objective decision making through all tiers of the plant from shop-floor to site leadership.
The role will be a key member of the Holly Springs Site Leadership Team, directing, managing and overseeing the development of site processes to ensure a zero-waste mentality across the plant. The site Head of OpEx will drive both strategic plans that deliver the site vision while disciplined tactical plans that deliver the day-to-day business. The Operational Excellence program will be the engine of Continuous Improvement driving a pipeline of Lean and Six Sigma projects while installing a Standard Lean Production System across all functions of the plant on Day 0. The role will work across Operations, Quality, Engineering and Supply Chain to deliver Industry Top Decile performance in SQDEC (Safety, Quality, Delivery, Engagement, Cost & Digital).
The role will also lead long-term site strategy setting and deployment to position the Holly Springs site as an industry leader in High-Volume, CVRM manufacturing for the future. The Head of OE will influence the organization to ‘bake-in’ Lean Principles, Operational Excellence and Continuous Improvement into the core DNA and culture of the plant.
You will manage the Operational Excellence team, Business Intelligence team, site Lean/Six Sigma program and matrixed into all on-site functions to deliver value.
You will create an environment of strong team spirit, urgency, timely and effective communications, high motivation and inspire teams to achieve goals in the immediate and longer term. Proactively promote positive Safety Culture and cGMP operating principles
You will be an active and visible change agent, promoting flexible and open mindsets to new opportunities.
You will establish strategic goals and objectives and maintain full strategic responsibility for the organization
You will drive collaboration within site and across network activities, cross-functional planning, and decision making
You will own the site Cost Improvement strategy to deliver on COGS goal.
You will embody operating principles and methods while fostering a continuous improvement mindset
You will be responsible for implementation and continuous improvement of business processes at the site (e.g., Business Process Management, Operations Reviews, Resource Management) to include establishing tiered business governance up to SLT.
Provides leadership for Lean Production System and coaching for improvement and optimization projects covering Safety, Quality, Delivery, Engagement and Cost (SQDEC).
Oversees business process management and the teams supporting continuous improvement
You will manage the Business Intelligence of the plant - developing, implementing and monitoring Site Goals and KPI’s with the IT/OT team.
You will provide oversight and ownership for the site Business Continuity Management
Who You Are
You have a Bachelor's Degree in engineering, technical or sciences with extensive Lean/Six-Sigma Black Belt Required (Master Black Belt preferred)
You have 15+ years’ work experience in the pharmaceutical, FMCG, food or device industry.
You have 10 years of leadership experience in Operations or Operational Excellence in Fast Moving, High Volume, Low Margin environment with demonstrated value delivery and site wide influence.
You have a proven track record of implementing continuous improvement programs with quantifiable business results
You have extensive experience working in and influencing decisions in matrix organizations
You have expert knowledge of network and site business developments, opportunities and challenges
You are able to think strategically and translate strategies into actionable plans
Excellent collaborator with cross-functional customers and network partners
You are able to foster a culture of continuous improvement
Monitors organizational performance through key performance indicators
You have advanced facilitation skills and change agent abilities
You build trustful and effective relationships
The expected salary range for this position based on the primary location for this position of Holly Springs is $206,000 - $384,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Link to Benefits
Relocation benefits are provided
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.