Research Scientist

Department:

Location:

Health Sciences Center

Time Type:

Full time

Worker Type:

Regular

Job Req ID:

R107999

Minimum Requirements:

Master's degree in a related field and four (4) years of relevant experience or an equivalent combination of education and experience. Grade 7 (Salaried)

Position Description:

We are seeking a highly motivated Research Scientist in the Department of Microbiology and Immunology to investigate the role of dysregulated innate immune signaling on alphaviral infection and pathogenesis. 

The ideal candidate will have experience in molecular and cellular biology, molecular virology, cellular and small animal models of alphaviral infection, rodent colony management, next-generation sequencing, and the quantitative and qualitative assessment of alphaviral pathogenesis. The position involves working with mouse models, as well as application modern multiomic technologies. This job requires data analysis and presentation at lab meetings, conferences, and other venues, as well as report preparation. The candidate will also be expected to mentor and direct trainees, such as summer interns and undergraduate students, as well as laboratory technicians and colleagues.

Essential Duties and Responsibilities

• Generate complex mouse models of alphaviral infection and evaluate innate immune signaling and inflammation both in vitro and in vivo.

• Conduct experiments to generate novel IRAK1 and inflammatory disease mouse models.

• Conduct cellular and molecular biology, virology, and immunology experiments to define the molecular mechanism and impacts of the dysregulation of IRAK1-dependent signaling are related to pathogenesis.

• Generate and analyze mice brain tissues for single cell sequencing, histology and spatial biology studies.

• Perform ELISA, RNA, DNA, immunohistochemistry, RT PCR, flowcytometry, microscopy, animal dissection and tissue collection experiments.

• Write and prepare the data for reports, publication and presentations. Preparation of manuscripts to publish the research findings.

• Review literature of the research areas and present the work at lab, university and national, international meetings.

• Mentoring the research technicians, summer and graduate students.

• This position includes project development towards grant preparation and submission.

Preferred Qualifications

• PhD, MD or DVM and 4 to 6 years of related experience with a strong background in viral pathogenesis, virology, molecular biology, cell biology, inflammation, and experience with mouse models of alphaviral infection. 

• Strong record of prior accomplishments as evidenced by at prior publication record.

• Knowledge of virology, innate immunology, histopathology, and inflammatory disorders.

• Commitment and passion to science.

Competencies

• Training in Western blotting, PCR, ELISA, Flow cyometry, Immunohistology, Confocal analysis, mouse and cell cultures handling, handling, modern virological techniques and animal colony management.

• Proficient in training and implementing new technologies.

• Strong organizational and project management abilities.

• Analytical and critical thinking skills. 

• Demonstrated work ethic and reliability.

• Excellent interpersonal, communication, and writing skills
  Effective team collaboration

Compensation will be commensurate to candidate experience.

Equal Employment Opportunity

The University of Louisville is an Equal Employment Opportunity employer. The University strives to provide equal employment opportunity on the basis of merit and without unlawful discrimination on the basis of race, sex, age, color, national origin, ethnicity, creed, religion, disability, genetic information, sexual orientation, gender, gender identity or expression, veteran status, marital status, or pregnancy. In accordance with the Rehabilitation Act of 1973 and the Vietnam Era Veteran Readjustment Act of 1974, the University prohibits job discrimination of individuals with disabilities, Vietnam era veterans, qualified special disabled veterans, recently separated veterans, and other protected veterans. The University acknowledges its obligations to ensure affirmative steps are taken to ensure equal employment opportunities for all employees and applicants for employment. It is the policy of the University that no employee or applicant for employment be subject to unlawful discrimination in terms of recruitment, hiring, promotion, contract, contract renewal, tenure, compensation, benefits, and/or working conditions. No employee or applicant for employment is required to endorse or condemn a specific ideology, political viewpoint, or social viewpoint to be eligible for hiring, contract renewal, tenure, or promotion.

Consistent with applicable law, demographic information is collected for aggregate reporting requirements. Demographic information provided through this application is not available to hiring managers/committees and is not considered in hiring or employment decisions.

Assistance and Accommodations

Computers are available for application submission at the Human Resources Department located at 215 Central Avenue, Ste 205 - Louisville, Kentucky 40208.

If you require assistance or accommodation with our online application process, please contact us by email at employment@louisville.edu or by phone 502-852-6258.