Our previous work has uncovered key mechanisms linking systemic changes to tumor initiation, single cell signatures of models of breast normal and cancer development and identified epigenetic and immune pathways that suppress tumor development, such as pregnancy-induced reprogramming and BPTF-dependent regulation of hormone responsiveness.
Ongoing and future projects aim to define immune-mediated mechanisms of cancer prevention, elucidate stromal–epithelial crosstalk driving tumor initiation and progression, and understand how prior childhood cancer and its treatment reshape mammary tissue and influence breast cancer susceptibility
The lab offers a highly interactive and collaborative environment with strong expertise in single-cell transcriptomics and epigenomics, mammary gland biology, cancer initiation, and organoid and in vivo modeling systems. We are committed to mentoring trainees and fostering independence, creativity, and career development.
Qualifications
PhD degree in biology, cancer biology, immunology, genomics, or related fields
Strong background in molecular and/or cellular biology
Experience with mouse models, genomics, or computational analysis is a plus
Demonstrated ability to work both independently and collaboratively
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