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The postdoctoral scholar will play a key role in the planning, design, and execution of mechanistic and translational tumor immunology research within the Song Laboratory. The primary objective of this position is to elucidate how T cell-NK cell interactions, immune regulatory circuits, and cellular state transitions shape responsiveness to cancer immunotherapies. Research efforts will extend to therapeutic modalities including immune checkpoint blockade, cytokine-based immune modulation, and engineered cellular therapies such as CAR-T platforms. The scholar will contribute to the development and refinement of innovative research methodologies and will independently design, optimize, and execute complex immunologic and molecular experiments across in vitro, ex vivo, and in vivo model systems.
Technical scope includes primary immune cell isolation and manipulation, high-dimensional flow cytometry, multiplex immune profiling, spatial and single-cell transcriptomics, and functional assays to evaluate immune activation, cytotoxicity, and persistence. Additional methods may involve CRISPR-based perturbations, viral vector engineering, and immune cell manufacturing workflows relevant to CAR-based therapies. In vivo responsibilities include murine tumor modeling, immune cell adoptive transfer, and therapeutic efficacy studies.
The postdoctoral scholar is responsible for analyzing and interpreting experimental datasets and will work closely with the principal investigator to prepare manuscripts, abstracts, and research reports for peer-reviewed publication and scientific conferences. They will also participate in the preparation of grant submissions and perform critical evaluations of relevant scientific literature to inform ongoing and future research directions. In addition to advancing their own research projects, the scholar will help train junior lab members, support daily laboratory operations, and ensure compliance with institutional, state, and federal regulatory standards, including biosafety and animal research guidelines.
Required Education and Experience:
Application Instructions: Candidates must submit a CV, a brief statement summarizing research interests and experience, and contact information for 3 references with the Workday application.
The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities. The Pelotonia Institute for Immuno-Oncology (PIIO) is a comprehensive bench-to-bedside research initiative focused on harnessing the body’s immune system to fight cancer at all levels —from prevention to treatment and survivorship.
Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.
Thank you for your interest in positions at The Ohio State University and Wexner Medical Center. Once you have applied, the most updated information on the status of your application can be found by visiting the Candidate Home section of this site. Please view your submitted applications by logging in and reviewing your status. For answers to additional questions please review the frequently asked questions.
The university is an equal opportunity employer, including veterans and disability.
As required by Ohio Revised Code section 3345.0216, Ohio State will: educate students by means of free, open and rigorous intellectual inquiry to seek the truth; equip students with the opportunity to develop intellectual skills to reach their own, informed conclusions; not require, favor, disfavor or prohibit speech or lawful assembly; create a community dedicated to an ethic of civil and free inquiry, which respects the autonomy of each member, supports individual capacities for growth and tolerates differences in opinion; treat all faculty, staff and students as individuals, hold them to equal standards and provide equality of opportunity with regard to race, ethnicity, religion, sex, sexual orientation, gender identity or gender expression.