Engineering Platform Lead - Oligonucleotides

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Engineering Platform Lead – Oligonucleotides

Robust, scalable manufacturing platforms are essential to delivering high‑quality clinical and commercial oligonucleotide products. At GSK, this means deploying GMP‑compliant, fit‑for‑purpose technologies across our internal manufacturing network and external partners to enable reliable scale‑up, seamless technology transfer, and cost‑effective commercial supply.

The Engineering Platform Lead sits within Process Technologies, Medicinal Global Clinical Manufacturing Organisation (GCMO), and acts as a platform engineering and GMP subject‑matter expert, following products and processes across the end‑to‑end development and manufacturing lifecycle. The focus is on ensuring product and process quality, reproducibility, scalability and long‑term manufacturability.

As an Engineering Platform Lead, you will be accountable for delivering efficient, timely and cost‑effective clinical trial manufacturing, in line with CMC project plans. You will also serve as the GMP manufacturing point of contact for designated platforms, guiding platform selection and ensuring alignment with regulatory and operational expectations.

You will play a critical role in bridging Research, Development and Manufacturing, ensuring that new capabilities developed in early phases can be successfully implemented within a GMP environment and translated into clinical and commercial supply chains.

This role involves close collaboration with Drug Substance Development, Drug Product Development, GCMO Pilot Plants, Contract Manufacturing Organisations (CMOs), MSAT and GSK manufacturing sites. Engineering Platform Leads are core members of the relevant Manufacturing Technology Teams (MTTs) and key contributors to GSK’s oligonucleotide manufacturing strategy.

In this role you will

• Ensure that appropriate platforms are used for GMP clinical trial material manufacture with scalability, manufacturability and commercial manufacture in mind.
• Provide technical expertise and lead aspects (project definition, equipment selection, procurement and commissioning / qualification) of internal GMP platform capital projects.
• Transfer platform knowledge as required to and from CMOs – including the support of assets that have been acquired or in licensed as well as those arising from internal discovery programmes.
• Represent CM&SC in terms of platform stewardship and collaborate with Drug Substance Development, Drug Product Development, GCMO Pilot Plants, CMOs and MSAT and GSC Manufacturing Sites.
• Support the generation and maintenance of Own and maintain product and process knowledge throughout the entire development life cycle, bridging Research / Early Development and Commercial Manufacturing Operations.
• Embed QbD, QF, PDVS, and GMPs in the GMP Mfg. network, ensuring Quality is respected while speed and agility are retained by aligning product development strategies with these key initiatives.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• Bachelor’s degree in chemical engineering, Mechanical Engineering, Chemistry, Bioengineering, Pharmacy, or other relevant discipline + experience in pharmaceutical manufacture and/or development.
• Experience with GMP manufacturing in Small Molecule drug substance, biological drug substance and sterile manufacturing operations across clinical and commercial manufacture.
• Experience of Process Design, Quality/ GMP, Project Management, Equipment maintenance and design in a pharmaceutical setting.
• Experience collaborating with cross-functional teams in a multicultural environment. Preparing and delivering written and verbal communications in a professional setting.
• Experience in leading a large matrix international organisation, build successful collaborations within and outside GMP manufacturing.
• Ability to work independently and set your own direction.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Master or PhD in chemical engineering, Mechanical Engineering, Chemistry, Bioengineering, Pharmacy, or other relevant discipline.
• Would be advantageous to have manufacturing, scale-up or development experience of Oligonucleotide or peptide manufacture, and enzyme reactions.
• Matrix management, communication, synthesis and analytical capacity, presentation skills, spoken & written English, influencing, and flexibility.
• Experience in facility design, equipment procurement, capital projects, facility qualification and commercial manufacture are highly desirable.
• Solid understanding of regulatory requirements and the GSK QMS.
• A solid understanding of the connections with key stakeholders (Clinical, Regulatory, DS and DP development, CMC Project Teams and GCMO, CSC and GSC groups) is considered advantage.

Closing Date for Applications – 7th May 2026

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Please take a copy of the Job Description, as this will not be available post closure of the advert. 
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

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