VP, Program Team Leader

Role Summary:

The Program Team Leader (PTL) is a passionate, globally minded drug developer who brings adaptable leadership, deep strategic product development expertise, and a relentless commitment to delivering transformative medicines to patients. As a highly visible leader, the PTL partners closely with an experienced Program Manager and a cross functional team to shape Program strategy, define goals and priorities, and chart an integrated plan that balances a future focused vision of global commercial access with the pragmatic decision-making needed to advance through complex development milestones. 

This role is based in Waltham, MA without the possibility of being a remote role. 

Primary Responsibilities Include: 

Program Leadership & Strategy 

• Lead a high-performing, cross-functional Program Team by defining both the what (strategy, priorities, deliverables, and resources) and the how (a healthy, collaborative, and sustainable team environment). 
• Establish, communicate, and continually evolve a robust Program strategy to deliver a life-changing medicine to patients in need. 
• Ensure alignment of research, nonclinical, clinical, regulatory, CMC, and commercial strategies with the overarching Program strategy. 
• Serve as the primary owner of Program recommendations across all stages of development, driving toward milestones, timelines, and value-creating decision points.

Decision-Making & Communication 

• Structure, facilitate, and drive timely, high-quality cross-functional decision-making with both the Program Team and senior leadership, ensuring all critical perspectives are appropriately considered. 
• Prepare and deliver high-impact materials for the Board of Directors, Scientific Advisory Board, and other key governance bodies. 
• Maintain clear, open, and proactive communication with senior leadership regarding Program strategy, progress, risks, dependencies, and resource needs.

Scientific & External Engagement 

• Stay abreast of emerging scientific and development trends in muscle diseases and oligonucleotide drug discovery and development. 
• Build a visible, credible presence within the KOL and patient advocacy communities for the relevant disease areas. 
• Participate in business development activities as needed, including opportunity evaluations and due diligence.

Organizational Leadership 

• Model and reinforce company values, especially during periods of rapid growth and change. 
• Serve as a primary advocate for the Program within the broader portfolio and corporate strategic context. 
• Collaborate with Finance and functional leaders to responsibly manage the Program budget. 
• Foster a culture of scientific excellence, innovation, open communication, and continuous improvement. 
• Actively coach and support team members to help them perform at their best, and identify or mitigate skill or capacity gaps within the team. 
• Consider needs of the Program in context of Dyne corporate strategy and priorities, as primary advocate for the Program among Dyne senior leadership 

Education and Skills Requirements

• Experience in Phase 1-3 drug development is required; product launch/early commercialization experience a strong plus
• Proven and respected leader with:
  • Advanced degree in Medical or Life Science, MD, PhD or MBA or equivalent
  • 20 years of experience in pharmaceutical industry in leadership positions in drug development and proven track record in driving Programs through IND, early clinical, pivotal stages and approval
  • And/or at least 12 years in pharmaceutical industry in significant development and/or commercial leadership or general management positions including working with development teams in cross-functional setting, with exceptional track record of delivering on business objectives, activity/milestones leading to filing and launching, and strong knowledge of neuromuscular diseases
  • Experience in rare genetic diseases preferred

Other key traits:

• Entrepreneurial team leader, able to shape and communicate the vision for an important therapeutic Program and guiding the development of the product strategy and its execution
• Insightful people leader supporting and coaching high-caliber functional experts to achieve their absolute best
• Collaborative corporate leader partnering with other senior leaders to shape and fulfil Dyne’s overall mission to develop and commercialize transformational therapeutics for people living with serious diseases
• Orientation towards collective achievement and team credit, combined with individual sense of responsibility and accountability for teamwork and product
• Adept at leading through ambiguity and provide steadiness and consistency among shifting priorities
• Comfortable with fast-paced and nimble organizational environment
• Demonstrated experience in building highly effective and motivated cross-functional teams and in guiding teams and organizations in making complex and high-stakes data-driven decisions
• Proven acumen for cross-functional leadership and influencing without direct authority, both among cross-functional team members and senior functional leaders
• Demonstrated scientific knowledge and curiosity necessary for thought partnership across all functions
• Proven ability to establish and maintain credible and trust-based relationships with external stakeholders (e.g., KOLs, patient advocacy groups, regulators or investors)
• Outstanding sense of urgency and ability to pace the team’s work to achieve milestone achievement in highly competitive landscape
• Excellent communication skills (verbal, written, presentation) and ability to clearly communicate complex ideas stakeholders and teams at all levels
• Natural focus on team dynamics and proven ability to coach and support team members to perform at their best
• Effective people-oriented collaboration skills in an environment with cross internal functional teams, and third-party collaborators/vendors
• Team player and mentor, who listens effectively and invites response and discussion
• Collaborator who communicates in an open, clear, complete, timely and consistent manner