Vice President, US Brand Lead – Sigvotatug Vedotin

ROLE SUMMARY

At Pfizer Oncology, we are committed to “Outdo Cancer” by advancing transformative medicines wherever we can make a profound difference in patients’ lives. With a leading portfolio across breast, genitourinary (GU), hematology-oncology, gastrointestinal, and thoracic cancers, we are building a pipeline designed to change standards of care—and to do it at scale.

The US Precision Medicine/Thoracic Franchise is poised for significant growth as we prepare for potential breakthrough launches, including Sigvotatug Vedotin (SGN-B6A), an investigational antibody-drug conjugate in development for non-small cell lung cancer (NSCLC) and other solid tumors. This is a rare opportunity for an enterprise commercial leader to build and lead the US strategy for a high-impact asset—shaping the go-to-market approach, accelerating readiness across functions, and bringing a differentiated value story to customers and patients.

As Vice President, US Team Lead, you will set the US brand vision and mobilize a cross-functional operating model spanning Commercial, Medical, Market Access, Insights & Analytics, and Global partners. You will be accountable for strategic choices, investment governance, and performance outcomes, while building an inclusive, high-performing team that can execute with speed, rigor, and integrity in a dynamic external environment.

• Lead end-to-end US strategy from pre-launch through launch and into sustained performance
• Lead the US brand team and cross-functional launch operating model
• Own investment governance and outcomes, partnering closely with Finance and senior franchise leadership
• Translate breakthrough science into impact for patients with NSCLC and other solid tumors

This is a builder’s role at the moment it matters most: taking a high-potential, highly visible oncology asset from pre-launch through launch and into sustained impact. You will have enterprise-level ownership—setting the US vision, making the strategic trade-offs, and mobilizing Commercial, Medical, Market Access, Insights & Analytics, and Global partners around a single, integrated plan.

For a talented, ambitious leader, this is a chance to define your legacy—with direct exposure to senior franchise and enterprise stakeholders, the opportunity to hire and shape a high-performing team, and the mandate to create a differentiated go-to-market story grounded in insight and evidence. If you’re energized by complexity, motivated by purpose, and driven to deliver results with integrity, this role offers the scale, autonomy, and mission to do your best work.

ROLE RESPONSIBILITIES

The Vice President, US Team Lead Sigvotatug Vedotin will report to the Franchise Lead, Precision Medicine/Thoracic and serve as the senior US commercial leader accountable for end-to-end pre-launch, launch, and post-launch performance. This leader sets the US brand vision, drives an integrated go-to-market strategy across Commercial, Medical, Market Access, and Global partners, and ensures disciplined governance, investment decisions, and execution.

• Build, lead, and inspire a high-performing US brand organization, establishing clear operating rhythms, talent development plans, succession pipelines, and an inclusive team culture.
• Own US P&L-aligned brand performance and all US pre-launch and launch activities, including strategic choices, investment governance, risk mitigation, and scenario planning in partnership with Finance and the franchise leadership team.
• Set the US go-to-market strategy and integrated launch plan, aligning with Global Brand Strategy, Market Access, Medical, and field leadership to deliver a cohesive, compliant customer experience.
• Provide executive leadership for development of best-in-class HCP and patient strategy, positioning, and omnichannel content; ensure message architecture and evidence story are optimized through strong partnership with Global, Medical, and Regulatory.
• Identify, prioritize, and resource growth opportunities across indication expansion, segmentation, and lifecycle levers; translate insights into strategic choices with clear value cases and measurable outcomes.
• Lead development of annual and multi-year strategic and operating plans, integrating HCP, patient, access, and field execution strategies grounded in customer insights and competitive dynamics.
• Establish performance management and analytics governance for US marketing initiatives, driving actionable insights, continuous optimization, and clear readouts to senior leadership to improve decision velocity and ROI.
• Lead brand financial stewardship, including Annual Operating Plan, latest estimates, and investment allocation decisions; ensure resources are deployed to maximize patient impact and business results.
• Champion deep customer insight generation (field, medical, analytics, payers, and key opinion leaders) and translate insights into differentiated strategy, messaging, and executional choices.
• Own agency ecosystem strategy and governance (AOR and specialty partners) and manage a significant A&P budget with rigorous ROI discipline, compliant review processes, and a focus on creative effectiveness and speed-to-market.
• Model and enforce a strong culture of compliance, quality, and integrity across all brand activities, ensuring adherence to Company policies, regulations, and Pfizer Values.
• Exhibit high performance, values driven approach to develop strategies, identify opportunities, and manage key issues to achieve commercial objectives.

BASIC QUALIFICATIONS

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

• The successful candidate will bring enterprise-level leadership and a track record of delivering results through scale, influence, and disciplined decision-making. This includes leading leaders, shaping strategy across a complex matrix, and building high-performing, values-driven teams that thrive in ambiguity and move with urgency.
• Bachelor’s degree required; advanced degree (MBA/PhD/MD) preferred.
• 15+ years of progressive biopharma/healthcare experience, including significant US commercial leadership experience in specialty and/or oncology markets; 13+ years with MBA
• Proven launch leader with end-to-end accountability for at least one major US product launch (pre-launch through post-launch performance), including omnichannel execution and field enablement.
• Demonstrated ability to lead through a complex matrix and partner at the executive level across Medical Affairs, Market Access, Field Leadership, Regulatory/Legal, Analytics, and Global teams.
• Strategic, enterprise mindset with demonstrated ability to make high-stakes trade-offs, build investment cases, and translate insights into clear choices and measurable outcomes.
• Executive presence with strong judgment, governance orientation, and the ability to escalate and resolve issues quickly while maintaining alignment across senior stakeholders.
• Exceptional communication and influencing skills—able to synthesize complexity into clear narratives for senior leadership and cross-functional teams.
• Demonstrated ability to build and run integrated operating models (cadence, governance, metrics) and lead large, cross-functional teams to deliver at pace and with quality.
• Significant people leadership experience, including leading leaders (e.g., Directors/Senior Directors) and building organizational capability through hiring, coaching, and succession planning.
• Demonstrated financial stewardship, including ownership of large budgets and experience with forecasting, performance management, and ROI-based investment decisions.
• Track record of delivering results in high-visibility, ambiguous environments with multiple priorities, strong compliance standards, and significant reputational and financial stakes.

PREFERRED QUALIFICATIONS

• Advanced degree (MBA/PhD/MD).
• Senior US brand/marketing leadership experience (e.g., US Brand Lead, Franchise Lead, or equivalent scope).
• Oncology launch experience strongly preferred; exceptional specialty launch leaders with clear oncology adjacency will be considered.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Ability to travel domestically (~20%) and internationally as needed for congresses, customer engagements, and key internal meetings.
• Ability to work on a computer for extended periods using common applications (Outlook, Excel, PowerPoint).

Other Job Details:

Last Date to Apply for Job: May 20th, 2026

Additional Location Information: New York, NY; Collegeville, PA; Cambridge, MA; Bothell, WA, Lake Forest, IL

Eligible for Relocation Package: No

#LI-PFE

The annual base salary for this position ranges from $274,000.00 to $456,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 30.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

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