TSMS Lab Sr. Principal Process Scientist

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Eli Lilly and Company: TSMS Lab Sr. Principal Process Scientist

Job Summary

Eli Lilly and Company is seeking a highly motivated and skilled TSMS Lab Sr. Principal Process Scientist to join our dynamic team. This role focuses on the development, optimization, and scale-up of peptide synthesis and/or purification processes.  Additionally, this role will be critical in advancing our peptide-based therapeutic pipeline through commercialization, ensuring robust, efficient, and scalable manufacturing processes.

Job Responsibilities

* Lead and execute laboratory-based research and development activities for the synthesis and/or purification of complex peptides, including solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis (LPPS).
* Design and perform experiments for process optimization, including reaction conditions, reagent selection, purification strategies (e.g., HPLC, preparative chromatography), and yield improvement.
* Troubleshoot and resolve technical challenges related to peptide synthesis and/or purification, applying a deep understanding of organic chemistry and peptide chemistry principles.
* Collaborate cross-functionally with medicinal chemists, analytical chemists, process engineers, and manufacturing teams to ensure seamless technology transfer and scale-up of peptide processes.
* Document experimental procedures, results, and conclusions thoroughly in laboratory notebooks and technical reports.
* Present findings and recommendations to project teams and senior management.
* Stay abreast of the latest scientific advancements in peptide chemistry, synthesis technologies, and purification techniques.
* Contribute to the development of intellectual property and patent applications.
* Adhere to all safety regulations and good laboratory practices (GLP).

Job Qualifications

* Ph.D. in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related scientific discipline with a strong emphasis on peptide synthesis and purification.
* Minimum of 3 years of relevant experience in peptide process development within a pharmaceutical or biotechnology setting (post-doctoral experience will be considered).
* Demonstrated expertise in both solid-phase and solution-phase peptide synthesis techniques.
* Proficiency in various preparative chromatography techniques, particularly HPLC and MPLC for peptide purification.
* Strong understanding of analytical techniques used for peptide characterization (LC-MS, NMR, UV-Vis, AAA, etc.).
* Experience with process scale-up and technology transfer to manufacturing is highly desirable.
* Excellent problem-solving skills and a strong ability to work independently and as part of a team.
* Outstanding written and verbal communication skills, with the ability to present complex scientific information clearly and concisely.
* Familiarity with cGMP principles and quality systems is a plus.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$66,000 - $171,600

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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