Transformative methods. Inquisitive minds. Life-changing foresight.
Trial Master File Document Coordinator
£30,000 - £34,000 plus benefits
Reports to: Clinical Operations Manager
Directorate: Research & Innovation
Contract: 2 year fixed-term contract
Hours: Full time 35 hours per week (Flexible working requests considered)
Location: Stratford, London Office-based with high flexibility (1-2 days per week in the office)
Closing date: 23:55pm Sunday 25 January 2026
Visa sponsorship: You must be eligible to work in the UK to apply for this vacancy. Cancer Research UK is not able to offer visa sponsorship.
Recruitment process: Competency based interview, followed by second stage on-site interview with a task.
Interview date: W/C 2nd February
At Cancer Research UK, we exist to beat cancer.
Cancer Research UK are looking for a Trial Master File Document Coordinator to join our Centre for Drug Developments Clinical Study Coordinator team, reporting into the Clinical Operations Manager.
The Cancer Research UK Centre for Drug Development (CDD) is the world's only charity-funded drug development facility. Our pioneering research is driven purely by the goal to see scientific breakthroughs bring benefits to patients sooner. CDD is the sponsor of early phase and precision medicine clinical trials in oncology agents. Our broad portfolio rivals that of a medium-sized pharmaceutical company, spanning antibodies, cell therapies, vaccines, drug conjugates and small molecules, making this an interesting and dynamic area to work in.
This is a two year contract specifically to work on our DETERMINE trial, our multi-drug, precision medicine platform trial for adults and children. It’s one of the UKs leading early phase oncology trials, and the first UK national precision medicine trial in rare cancer.
In this role you will use your experience of Trial Master File Document Management to aid in the development of new cancer therapies by leading Trial Master File (TMF) activities for CDD Studies in accordance with Cancer Research UK Standard Operating Procedures (SOPs) and policies, ICH GCP guidelines, UK legislations and other regulatory requirements.
You could currently be working in a TMF role within a clinical trial environment looking to develop Trial Master File knowledge within a cause driven environment that has direct impact on patient benefit. Or you could be a Trial Coordinator or Clinical Trail Assistant looking for that next step to move into a TMF role.
Whatever your background you’ll preferably need to bring previous experience of Trial Master File Document Management including a strong knowledge of clinical study documents and experience in a supportive role.
What will I be doing?
Ensure compliance with Centre for Drug Development (CDD) SOP’s and procedures to assist with maintaining an inspection ready eTMF.
Ensure completeness of the eTMF through regular eTMF reviews.
Perform Quality Checks of documents to ensure a high level of document quality.
Maintain awareness of study events related to documents required for the TMF.
Filing of study team TMF documents within the required timelines.
Resolving and assisting with any queries relating to TMF documents and the study.
Running eTMF metric reports as required and assisting with updates to the study TMF Plan.
Review of documents received from sites, if required.
Sending required documents to sites in accordance with CDD procedures, if required.
Review of localised site documents, if required.
Managing study level eTMF access and site set up, if required.
Assisting with study specific TMF audit actions, if required.
Reconciliation of TMF and Investigator Trial File (ITF) documents, if required.
Participate as a member of the TMF Champions Group to support eTMF processes across CDD.
Leading on study specific TMF archiving activities.
Other TMF activities or support for the project team as required.
What are we looking for?
Previous experience of Trial Master File Document Management including a strong knowledge of clinical study records.
Knowledge of ICH GCP.
Knowledge of the TMF Reference Model.
Strong attention to detail.
Proficient in the use of Microsoft Office (TM) – Word, PowerPoint and Excel.
Experience supporting multiple people.
Strong organisational skill and the ability to manage multiple priorities.
Ability to problem solve and escalate issues where appropriate.
Relevant experience working with an eTMF, Veeva Vault is preferred.
Our organisation values are designed to guide all that we do.
Bold: Act with ambition, courage and determination
Credible: Act with rigour and professionalism
Human: Act to have a positive impact on people
Together: Act inclusively and collaboratively
We’re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.
If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience, we’d still love to hear from you.
What will I gain?
We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.
You can explore our benefits by visiting our careers web page.
How do I apply?
We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.
For more information on this career opportunity please visit our website or contact us at recruitment@cancer.org.uk.
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Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented.
We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact recruitment@cancer.org.uk or 020 3469 8400 as soon as possible.
Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.