Sr. Manager, Clinical Bioinformatics

About the Role:

The Director of Clinical Bioinformatics, reporting to the VP, Clinical Applications, will lead the design, development, and implementation of computational pipelines and analytical frameworks supporting 10x Genomics clinical diagnostics. This role will bridge advanced single-cell and spatial genomics with clinical assay development and CLIA operations, ensuring analytical rigor, reproducibility, and compliance.

The ideal candidate is a hands-on bioinformatics leader with deep expertise in NGS, single-cell, and spatial data analysis, combined with a strong understanding of clinical-grade bioinformatics analysis. This position will partner closely with the Director of Diagnostic Assay Development and the Director of the CLIA Laboratory to enable end-to-end translation of 10x technologies into clinical use.

What You Will Be Doing:

Scientific and Translational Excellence

• Partner with the Diagnostic Assay Development team to integrate informatics approaches into assay design, validation, and performance optimization.
• Drive biomarker discovery and translational analyses in large-scale clinical research studies, including partnerships with leading academic centers processing thousands of tumor and blood samples.
• Work with external collaborators to generate and interpret data that demonstrate clinical validity and utility.
• Implement robust statistical and computational frameworks to address batch effects, confounding variables, and data harmonization across studies.
• Serve as the bioinformatics representative in external 10xDx translational and clinical collaborations.
• Maintain deep familiarity with emerging bioinformatics methodologies and clinical genomics standards.

Computational and Analytical Leadership

• Lead the design, implementation, and optimization of bioinformatics pipelines for single-cell and spatial genomics data, from raw data to clinical interpretation.
• Establish, maintain, and operate CLIA-compliant computational workflows, documentation, and quality systems in collaboration with the CLIA Laboratory Director
• Be responsible for data quality control and patient data reporting
• Develop and validate algorithms, statistical models, and quality metrics for clinical assay performance.
• Direct analytical validation of bioinformatics components in support of LDT assays.
• Ensure computational reproducibility, version control, and auditability aligned with CLIA and CAP standards.

Operational Leadership

• Build and lead a high-performing team of bioinformaticians, fostering technical excellence and accountability.
• Partner with broader R&D computational biology team for method development and platform improvements
• Define team goals, deliverables, and metrics supporting diagnostic R&D milestones.
• Establish data management and computational infrastructure in collaboration with IT, Quality, and CLIA lab teams.
• Support publication-quality analyses and contribute to scientific manuscripts and presentations at major conferences.

Collaboration and Strategic Integration

• Work closely with clinical, laboratory, and assay development teams to design studies, interpret results, and implement findings into diagnostic workflows.
• Collaborate with regulatory and quality leaders to ensure data integrity and compliance in all analytical systems.
• Serve as the bioinformatics representative during audits, partner reviews, and cross-functional readiness assessments.
• Contribute to defining the broader clinical bioinformatics strategy and diagnostic roadmap for 10xDx.

To Be Successful in this Role you will need:

• Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related field.
• Minimum 10 years of experience in bioinformatics for clinical or diagnostic applications, including leadership of high-impact computational teams.
• Deep expertise in NGS, single-cell, and/or spatial data analysis, from primary data processing through interpretation.
• Proficiency in R, Python, and major bioinformatics toolkits; familiarity with cloud or high-performance computing.
• Demonstrated success collaborating with experimental scientists and clinicians on translational and diagnostic projects.
• Strong publication record in computational biology, genomics, or diagnostics.

Additionally, you are:

• Detail-oriented and quality-driven, with a deep respect for validation and rigor.
• Strategic thinker who also thrives in hands-on analytical and computational work.
• Effective communicator and collaborator across scientific, operational, and executive teams.
• Motivated by building new capabilities at the intersection of genomics, computation, and clinical medicine.

 

This is a key leadership position within 10x, defining and operating the computational and analytical framework for clinical implementation of single-cell and spatial diagnostics. The Director of Clinical Bioinformatics will ensure that data analysis pipelines, algorithms, and interpretation frameworks meet the highest scientific and quality standards—enabling 10x to deliver clinically meaningful insights that advance precision medicine.