Senior Scientist Computational Chemistry

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients. 

About the role
Argenx is establishing a new department dedicated to small molecule and peptide drug discovery.  We are seeking an experienced Computational Chemist (8+ years in biopharma) to lead computational approaches for small molecule drug discovery. This role combines structure-based drug design (SBDD) expertise with strategic vision for leveraging AI-driven models and external partnerships. You will set up the in silico design ecosystem (software implementation, selection of CRO’s or expert consultants) in order to enable data-driven optimization of drug candidates.

This position is based at our facility in Zwijnaarde (Ghent), and expects on-site presence.

Key Responsibilities

Structure-Based Drug Design (SBDD)

• Shorten DMTA cycles by in silico filtering of new design ideas. Collaborate with medicinal chemists to optimize potency and selectivity.
• Set up a software ecosystem (in house or through collaboration) that enables you of interpreting structural biology data and allowing to dock and rank new molecules.
• Stay abreast of cutting edge technologies like AlphaFold, OpenFold, Boltz or any emerging convolutional models for protein-ligand interaction insights.
• Collaborate with structural biology group in Argenx to obtain an in silico design ecosystem fully integrated with ongoing efforts.
   

AI-Driven Predictive Modeling

• Shorten DMTA cycles by implementing models (through collaboration, CRO, expert consultants) that aid obtaining a drug like molecule. Collaborate with both medicinal chemists and ADMEt/DMPK expert.
• Identify and manage partnerships with leading AI/ML platform providers.
• Leverage state-of-the-art models for potency, ADME/Tox prediction, and generative design.
• Provide strategic input on realistic applications of AI in drug discovery.
   

Data Integration & Visualization

• Aid in the aggregation and harmonization data from CROs and internal sources.
• Leverage different data streams to obtain better predictive models.

Profile

• PhD or equivalent in Computational Chemistry, Cheminformatics, Structural Biology, or related field.
• 8+ years of experience in computational chemistry within biopharma or biotech.
• Proven expertise in SBDD, virtual screening, and molecular modeling.
• Hands-on experience with AlphaFold or similar protein prediction tools.
• Familiarity with AI/ML applications in drug discovery and ability to evaluate external platforms.
• Strong understanding of medicinal chemistry principles and drug-likeness.
• Experience managing CROs and external technology partnerships.
• Ability to work independently and collaboratively within a team.
• Excellent communication and interpersonal skills for effective collaboration.
• Fluent in written and spoken English to ensure clear and effective information exchange.  
• Demonstrated ability to take initiative and address challenges proactively.
• Dynamic and practical problem-solving approach with a focus on delivering tangible results.
   

Offer

• The opportunity to establish a new role within the organization, contributing to shaping its future direction.
• A competitive salary package accompanied by comprehensive benefits.
• Working in a human-sized, dynamic, rapidly growing biotech company, providing an engaging work environment.

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At argenx, all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer.

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