Senior Manager, Contracts - Clinical

The Role:

Reporting to the Head of Contracts, the Senior Manager, Contracts - Clinical will serve as the primary contracts professional working closely with the Clinical function, particularly Clinical Operations. This is a hands-on, high-volume role responsible for the full lifecycle of clinical site agreements and ancillary clinical contracts across Nuvalent’s global study portfolio, currently spanning four concurrent studies including a Phase 3 randomized controlled trial.

The ideal candidate has deep experience in global clinical site contracting at a sponsor company or CRO, is comfortable operating with significant autonomy, and has the judgment to know when to resolve an issue independently and when to escalate. This role works directly alongside a peer team of Senior Contracts Managers within a contracts department that is growing alongside Nuvalent’s pipeline.

 

Responsibilities:

Clinical Site & Study Agreements

• Draft, review, negotiate, and execute Clinical Trial Agreements (CTAs) with academic medical centers, community research sites, and international investigator sites across global markets.
• Manage the full contract lifecycle from initial draft through execution, amendment, and close-out across a high-volume, multi-study portfolio.
• Coordinate Informed Consent Form (ICF) review as needed in connection with site-level contracting.
• Negotiate and process Work Orders (WOs) and Change Orders (COs) in coordination with Clinical Operations and relevant CRO or vendor counterparties.
• Serve as the primary contracts point of contact for site administrators, legal counsel, and CRO contract teams, maintaining productive counterparty relationships through complex negotiations.

Ancillary Clinical Contracts

• Draft, review, and negotiate Confidential Disclosure Agreements (CDAs) and Non-Disclosure Agreements (NDAs) for clinical partnerships and site-level engagements.
• Manage consulting agreements for clinical investigators, key opinion leaders, and clinical consultants engaged by Clinical and Clinical Operations, with appropriate escalation of HCP engagements for compliance review.
• Support statements of work and related agreements for Clinical and Clinical Operations vendors.

Contract Operations & Process

• Maintain accurate, complete, and timely contract records in Nuvalent’s contract management system (Agiloft), including status updates, executed document storage, and obligation tracking.
• Apply and enforce departmental file naming conventions, version control standards, and repository management protocols.
• Provide timely contract status visibility to Clinical and Clinical Operations business owners and serve as a reliable point of contact for internal stakeholders throughout the contract lifecycle.
• Identify issues requiring escalation and engage appropriate internal resources — including Legal, QA, Regulatory, Clinical Operations, Finance, IT, and Compliance — or external resources including CRO counterparties, outside counsel, or the Data Privacy Officer (DPO).
• Contribute to negotiation playbooks, standard fallback positions, and contract templates for clinical contract types.
• Coordinate with Legal and the DPO on data privacy provisions in clinical agreements, including GDPR data processing terms for EU and international site agreements.
• Utilize AI-assisted contract review tools as integrated into departmental workflow in accordance with established Nuvalent guidance.
• Lead or co-lead department initiatives to support an expanding organization.

 

Competencies Include:

• Detail and process oriented, with strong organizational skills and the ability to manage a high-volume, multi-study contract portfolio across competing deadlines and shifting priorities.
• Strong negotiation, problem solving, and communication skills, with the ability to hold a position, find common ground, and close without unnecessary escalation.
• Flexibility with changing priorities and ability to think critically under pressure.
• Ability to work in a collaborative environment and build effective working relationships across the organization, including with external counterparties such as site administrators, CRO contract teams, and outside counsel.
• Sound judgment in recognizing when to resolve independently and when to bring in the right internal or external resources.
• Able to thrive in a remote/virtual environment.

 

Qualifications:

• Minimum of 7 years of contracts experience in the biopharmaceutical or clinical research industry, with at least 4 years focused on vendor agreements, clinical site agreements, investigator agreements, or study start-up contracting; sponsor-side experience preferred, CRO-side experience considered.
• Demonstrated experience negotiating CTAs, WOs, COs, CDAs, and HCP consulting agreements at volume across multiple concurrent studies.
• Direct experience contracting with international clinical sites and working knowledge of applicable legal and regulatory requirements including GDPR data processing considerations.
• Working knowledge of GCP, ICH guidelines, and FDA regulations governing clinical research and their practical implications for contract terms.
• Familiarity with IRB processes and their intersection with site-level contracting.
• Proficiency with contract lifecycle management systems; experience with Agiloft, Ironclad, DocuSign CLM, or comparable platforms required. Agiloft experience a plus; training will be provided.
• Oncology experience preferred; relevant experience from adjacent therapeutic areas will be considered.
• Familiarity with AI-assisted contract review tools a plus.
• Bachelor’s degree or equivalent experience required.

 

Additional Information:

Nuvalent is committed to fair and equitable compensation practices, aiming to provide employees with competitive total rewards packages.

The targeted salary range reflects what Nuvalent reasonably and in good faith expects to offer for this position at the time of posting, but the final salary determination may be within or outside this range based on various factors, including, but not limited to, experience, skills, education, and market factors.  The range will be reviewed regularly and is subject to change.

Nuvalent also offers a comprehensive benefit package to support our employees at each stage of their career, financial, health, and well-being journey, including medical, dental, and vision insurance, 401(k) retirement savings plan, generous paid time off (including a summer and winter company shutdown), and much more.