Scientist - Immunology

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly Immunology Discovery is seeking a motivated, detail-oriented and highly skilled scientist to join the Lilly South San Francisco team, contributing to preclinical drug discovery efforts for immune related diseases. The ideal candidate will leverage their technical expertise to thoughtfully design, execute and analyze cellular biology experiments that address key biological questions, as well as develop and implement medium-high throughput assays for evaluating drug candidates. Success in this position requires a proven track record of working with primary and immortalized cells, as well as proficiency in flow cytometry-based readouts and immunoassays. Exceptional problem-solving skills, adaptability and capability of independently running high-quality studies are essential for thriving in this collaborative and fast-paced environment.

Primary Responsibilities:

• Design, execute, and troubleshoot in vitro cellular biology experiments to investigate disease biology and study mechanism of action of drug candidates, including but not limited to flow cytometry, luminescence/fluorescence assays and immunoassays (e.g. ELISA).
• Develop medium-to-high throughput cellular and whole blood assays for evaluating small molecule inhibitors.
• Purify PBMCs and primary immune cells from human blood and maintain primary and immortalized cell cultures.
• Maintain accurate, organized records of experimental data and protocols in electronic lab notebooks.
• Analyze, interpret and clearly communicate experimental findings and recommendations to project leads and cross-functional project teams.

Basic Requirements:

• Bachelor's degree in cell biology, immunology or a closely related scientific field.
• 3+ years of laboratory research experience, preferably in industry settings.

Additional Skills/Preferences:

• Working knowledge of cell biology concepts and understanding of assay principles.
• Hands-on experience with cell lines, whole blood and isolation/culture of primary immune cells (from human blood).
• Experience with immunoassays (ELISA/MSD/HTRF), multi-color flow cytometry (staining, acquisition, analysis using FlowJo) and protein detection (e.g. Western blotting).
• Experience with cellular and biochemical assays in 96- and 384-well format.
• Research experience working with small molecules, as well as experience with qPCR and CRISPR, would be advantageous.
• Proven ability to work both independently and collaboratively within a research team.
• Excellent communication, time management, and record-keeping skills.
• Data analysis using GraphPad Prism and Excel.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$65,250 - $148,500

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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