SUMMARY:
The Scientist III will support multidisciplinary research teams by designing and executing preclinical in vivo studies in rodents. The successful candidate will integrate pharmacokinetics with pharmacodynamics/efficacy and/or toxicology to provide assessments around drug exposure relationship to target-engagement/efficacy and/or tox signals.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
Design and execute in vivo studies in both rat and mouse models and work with key stakeholders to provide interpretation around the pharmacokinetics, pharmacodynamics, efficacy, and toxicology of preclinical drug candidates.
Coordinate with various functional groups, including PK, toxicology, pharmacology, formulation, and bioanalytical sciences, to ensure timely data delivery.
Collaborate with various scientific functions within project teams to design in vivo studies to address hypotheses.
Prepare and organize data for presentation using analysis and visualization software, present data and reports on project status at individual, group, and departmental research meetings.
Maintain laboratory notebook in a complete, consistent, and concise manner following company intellectual property policies and practices.
Adhere to good health and safety practices, comply with applicable EH&S rules, and participate in mandatory safety training programs.
Collaborate with the IACUC committee to ensure compliance with internal policies and animal welfare regulations.
Maintain familiarity with current scientific literature relevant to the research experiments or program.
Foster a science-driven, goal-oriented culture that values innovation, teamwork, agility, transparency, accountability, and empowerment.
SUPERVISORY RESPONSIBILITIES:
None
EDUCATION/EXPERIENCE/SKILLS:
Education:
BS degree in a related discipline and a minimum of three years of related industry experience; or,
Master's degree in a related discipline and a minimum of one year of experience; or,
Equivalent combination of education and experience.
Experience:
Proficient with in vivo techniques, including animal handling (mouse and rat), different dosing routes (IV, IP, SC, PO, IM, etc.), blood collection techniques (tail vein, RO, cardiac puncture, etc.), and tissue collection/necropsy in rat and mouse.
In-depth experience with animal tumor model development and execution; including, but not limited to syngeneic, xenograft, PDX and humanized mouse models is required.
Expertise in cell culture with aseptic technique and scale-up for tumor implantation is required
Experience in pre-formulation for small molecules is a plus.
Proven track record of good experimental design, in-depth data analysis, and interpretation based on strong scientific rationale.
Knowledge/Skills/Abilities:
Strong knowledge and skills in working with rats and mice, as well as intimate knowledge of formulating in vivo study protocols, IACUC protocols, AAALAC guidelines, and vivarium techniques/best practices, are a must.
In-depth knowledge of pharmacokinetics and/or toxicology and/or pharmacology is preferred.
Works independently; self-motivated, innovative, and proactive in identifying and troubleshooting issues.
Has flexibility to accommodate a fast-paced work environment and deadlines and the ability to work under specific time constraints.
Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in a team environment or independently.
Advanced knowledge of MS Office, PDF, GraphPad, ELN notebook, and Studylog is required.
JOB COMPLEXITY:
Work on problems of diverse scope where data analysis requires evaluating identifiable factors.
Exercise judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions.
Occasional weekend and holiday work will be required to support in vivo studies.
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If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!
Our compensation reflects the cost of labor across several U.S. geographic markets, and we pay differently based on those defined markets. The base pay range for this position is $89,500 - $127,500 annually. The base pay range may take into account the candidate’s geographic region, which will adjust the pay depending on the specific work location. The base pay offered will take into account the candidate’s geographic region, job-related knowledge, skills, experience and internal equity, among other factors.In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year.DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.