Scientist I, DMPK

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease.

At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.

Visit our website to learn more about our company and culture!
Site: www.ptcbio.com

Job Description Summary:

The Scientist I, DMPK is responsible for planning and performing in vitro ADME assays that contribute to PTC’s research and drug discovery activities. The incumbent is also responsible for communicating experimental results to his/her supervisor and the project team.

The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC’s discovery science project teams.

The Scientist I, DMPK supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.
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Job Description:

ESSENTIAL FUNCTIONS

Primary duties/responsibilities:

• With limited guidance, plans, initiates and executes DMPK studies and interprets and communicates results as part of a multi-disciplinary team.

• Performs hands-on in vitro drug metabolism assays, including solubility, plasma protein binding, tissue binding, B/P ratio, LogD/LogP/pKa measurement, and metabolic stability, etc.

• Develops and implements bioanalytical methods (LC-MS/MS).

• Collaborates with discovery teams to design and conduct in vitro drug metabolism assays.

• Interprets and presents data/results to internally and externally in cross-functional teams.

• Documents experiment details in laboratory notebook and writes reports.

• Ensures the scientific quality of the experimental data.

• May provide oversight, and/or lead interactions with, the external Contract Research Organizations (CROs).

• Abides by all safety and regulatory guidelines.

• Contributes to general lab needs such as:
  • Equipment maintenance
  • Troubleshoot

• Performs other tasks and assignments as needed and specified by management.

KNOWLEDGE/SKILLS/ABILITIES REQUIRED

• Hands-on experience in in vitro ADME screening assays.

• Knowledge of drug metabolism in discovery preclinical research.

• Knowledge in the principles of LC-MS/MS based small molecule bioanalysis.

• Experience in developing protocols and writing study reports.

• Ability to work on complex problems to produce experimental data across one or more projects.

• Ability to work independently and collaboratively in a fast-paced, matrixed, team environment consisting of internal and external team members.

• Ability to work effectively in a multi-disciplinary team environment.

• Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.

• Proficiency with Microsoft Office.

• Excellent verbal and written communication skills.

• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.

* Minimum level of education and years of relevant work experience.

• PhD in biology, pharmaceutical science, pharmacology, or other related scientific discipline OR a Master’s degree in these same disciplines and a minimum of 3 years of experience in drug metabolism in a pharmaceutical, biotechnology or related environment.

*Special knowledge or skills and/or licenses or certificates preferred.

• Hands on experience in operating and general troubleshooting of contemporary LC-MS instruments and automated liquid handlers.

• Hands on experience with cell cultures.

* Travel requirements

•  0-10%
• Laboratory based position.

Expected Base Salary Range

$111,400 - $133,000. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity.

In addition to base salary, PTC employees are also eligible for short- and long-term incentives. All eligible employees may also enroll in PTC’s medical, dental, vision, and retirement savings plans.

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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