Scientist

Deliverables:

• Work products and documents related to implement and performing studies that are aimed at detecting age-associated changes in Protein Quality Control; perform longitudinal and cross-sectional design experiments. - Ad-Hoc

• Work products and documents related to protein chemistry, assessment of protein posttranslational modifications, protein-ligand binding, protein-protein interactions, protein extraction/quantitation from cell and tissue lysates, with a strong technical background in immunolabeling. - Ad-Hoc

• Work products and documents related to implementing protein assays and immunolabeling assays; conduct specific, technical enzymatic and protein analyses, and data reduction; perform and analyzed implemented assays. - Ad-Hoc

• Work products and documents related to collecting, analyzing and interpreting data; update and maintain laboratory notebooks and databases; prepare summaries and reports based on results and findings. - Ad-Hoc

• Work products and documents related to writing scientific manuscripts; submit drafts for editing and approval; develop and deliver presentations; attend laboratory meetings; present results and findings for staff discussion. - Ad-Hoc

• Clean Equipment - Ad-Hoc

• Meet with lab members to present updates - Weekly

Statement of Work Details:

• Implement and perform studies that are aimed at detecting age-associated changes in Protein Quality. - 1
• Perform longitudinal and cross-sectional design experiments that span an estimated four-year period involving aging mice, via a multiomics approach as determined by the laboratory. - 2
• Participate in the writing of scientific manuscripts generated using data collected from the studies and analyzes conducted; submit drafts for editing and approval. - 3
• Implement and perform studies that are aimed at detecting age-associated changes in Protein Quality. - 4
• Perform longitudinal and cross-sectional design experiments that span an estimated four-year period involving aging mice, via a multi-omics approach as determined by the laboratory. - 5

• Supports the planning and execution of research experiments in the context of the laboratory's overall research program.

• Evaluate new techniques, instruments, and software for potential incorporation into current SOP.

• Advance the science in the laboratory through new procedures and discoveries.

• Advance the science through proposing and investigating new target projects for initiation based on novelty and relevance to human health.

• Supports laboratory staff on research projects and techniques.

• Work with staff on the interpretation of experiments performed by research scientists.

• Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis in the development of novel research treatments.

• Work with postdoc/biological scientists to perform statistical analysis for research projects.

• Work with staff on assay design and method development using an array or experimentation.

• Review scientific data to determine if a research program can be developed around an idea or data package.

• Work with staff on protein chemistry, assessment of protein post-translational modifications, protein-ligand binding, protein-protein interactions.

• Collaborate with staff on protein extraction/quantitation from cell and tissue lysates, with a strong technical background in immunolabeling (western blotting, immunofluorescence/immunohistochemistry, and immunoprecipitation).

• Implementing protein assays and immunolabeling assays.

• Maintains laboratory equipment and the training of others in their use.

• Calibrate, maintain and troubleshoot instruments and equipment in the laboratory.

• Maintain and perform staff training on scientific instrumentation, including HPLCs, microanalytical balances, centrifuges, spectrophotometers, vacuum apparatus and analytical equipment.

• Operate, troubleshoot and train others to use laboratory equipment and software.

• Provide advice and assistance to users in designing experiments, using instrumentation, data acquisition and analysis, and preparing figures for publication.

• Assists in maintaining adequate space and facilities for ongoing and projected research studies.

• Manage scientific equipment and resources (e.g. reagents, stocks of frozen sells, animal samples) including acquisition, documentation and storage.

• Participate in the laboratory’s review of future proposals for resource allocations. Evaluates, analyzes and interprets research data, communicates results and methods in reports, presentations, and manuscripts.

• Write technical reports and prepare manuscripts.

• Oversee project data quality; analyze and interpret project data.

• Conduct bioinformatics data analyses and statistical analyses; prepare data for abstracts and manuscripts.

• Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments.

• Conduct specific, technical enzymatic and protein analyses, and data reduction.

• Perform and analyzed implemented assays.

• Collect, analyze and interpret data; update and maintain laboratory notebooks and databases.

• Coordinates with junior staff to modify research protocols.

• Work with staff to confirm assay results and evaluate new techniques and instruments; search literature; propose, design and test alternative assays for difficult screening targets; confirm assay results; develop secondary assays.

• Work with Principal Investigators in scheduling and prioritizing instrument usage.

• Coordinate projects being developed in the laboratory, proposing SAR strategies and monitoring their progress.

• Coordinate with IT staff on all software issues specific to the chemistry group and on all computer problems.

• Identify and advise IC leadership on opportunities and program areas, research gaps and relevant program needs; make recommendations for consideration.

• Participate in establishing criteria and standards for others to follow in the planning, review and evaluation of bioinformatics research projects.

• Suggest alternative or complementary approaches to experiments.

• Presents research at national scientific meetings and symposia.

• Prepare oral presentations and posters for internal and external groups/conferences.

• Co-author manuscripts on research projects; publish in peer-reviewed journals.

• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals; prepare PowerPoint presentations as appropriate.

• Give posters and presentations detailing work at regional and national scientific meetings.

• Review, edit, and, as needed, write first drafts of papers, posters and manuscripts.

• Give posters and presentations detailing work at regional and national scientific meetings.

• Present results of clinical and experimental research at recognized scientific meetings by lectures and exhibits (poster sessions).

• Develop and deliver presentations using data collected from the studies and analyses conducted.

• Attend laboratory meetings; present results and findings for staff discussion.

• Provides interpretation of results, guidance, and scientific support to the management team.

• Search existing literature for new and/or relevant techniques.

• Assist the lab staff in the creation and preparation of a variety of documents required by the lab’s scientific activities.

• Produce research reports and regularly communicate results to staff and collaborators.

• Prepare information for and attend advisory, review committee and panel meetings; respond to issues and concerns about specific applications/proposal pertaining to assigned program area.

• Prepare summaries and reports based on results and findings.

• Mentors junior level scientists.

• Train staff on the proper usage of equipment.

• Train staff in a wide variety of techniques used in the laboratory.

• Train staff in the proper breeding/genotyping techniques used to maintain various knock out, knock in, and transgenic lines used by the laboratory members.

• Provide scientific and technical expertise to all visiting fellows, post-docs, and technicians.

• Work with staff on protein chemistry, assessment of protein post-translational modifications, protein-ligand binding, protein-protein interactions.

• Collaborate with staff on protein extraction/quantitation from cell and tissue lysates, with a strong technical background in immunolabeling (western blotting, immunofluorescence/immunohistochemistry, and immunoprecipitation).

• Implementing protein assays and immunolabeling assays.

• Conduct specific, technical enzymatic and protein analyses, and data reduction.

• Perform and analyzed implemented assays.

• Collect, analyze and interpret data; update and maintain laboratory notebooks and databases.

• Prepare summaries and reports based on results and findings.

• Participate in the writing of scientific manuscripts generated using data collected from the studies and analyzes conducted; submit drafts for editing and approval.

• Develop and deliver presentations using data collected from the studies and analyses conducted.

• Attend laboratory meetings; present results and findings for staff discussion.