Protein Engineering Scientist, Gene Therapy Engineering

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

Perform protein engineering to advance the development of novel gene therapies. Will design and perform protein variants and conduct in vitro screening for improved tropism and other critical attributes. Working with our Collaboration Partners and internal colleagues in Research, CMC, and Business Development, the individual will participate in work on new and existing programs.

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Your Contributions (include, but are not limited to):

• The primary role is to design, produce, and screen novel proteins modification of differing biological modalities to advance gene therapy programs
• Apply rational structural and computational approaches in protein engineering for improved attributes aligning with program goals
• Design and execute molecular biology and in vitro experiments in support of gene therapy programs
• Independently recommend alternatives, research new methods and techniques, and proactively seek out senior personnel to discuss potential solutions
• Prepare data summaries and present results to peers and colleagues at Neurocrine
• Provides training and/or supervision to junior staff, as needed
• Other tasks as assigned
• The primary role is to design, produce, and screen novel proteins modification of differing biological modalities to advance gene therapy programs
• Apply rational structural and computational approaches in protein engineering for improved attributes aligning with program goals
• Design and execute molecular biology and in vitro experiments in support of gene therapy programs

Requirements:

• BS/BA degree in biology and 2+ years of relevant experience OR

• MS/MA degree in biology and some relevant industry experience preferred OR

• PhD or equivalent and some relevant experience

• Knowledge of protein engineering, including structural analysis and application of computational approaches

• Expertise in molecular biology, including techniques such as biology techniques such as PCR, digital PCR, gel electrophoresis, western blot/ELISA, plasmid design, cloning, and sequencing

• Experience in cell culture work, especially AAV or antibody production, including plasmid transfection, cell material processing, and purification

• Programming proficiency is strongly preferred, especially in Python

• Familiarity with protein engineering tools, such as PyMol, MolStar, and AlphaFold; experience with ML applications such as DiffDock, BoltzGen, etc. are a plus

• Backgrounds in neuroscience and/or sequencing technologies are a plus

• Excellent critical analysis skills and ability to assess data and research findings outside of Neurocrine for application to new scientific projects

• Advanced knowledge and demonstrated ability to work with a variety of laboratory equipment/tools

• Ability to work as part of teams

• Excellent computer skills

• Excellent communication skills

• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency

• Knowledge of protein engineering, including structural analysis and application of computational approaches

• Expertise in molecular biology, including techniques such as biology techniques such as PCR, digital PCR, gel electrophoresis, western blot/ELISA, plasmid design, cloning, and sequencing

• Experience in cell culture work, especially AAV or antibody production, including plasmid transfection, cell material processing, and purification

• Programming proficiency is strongly preferred, especially in Python

• Familiarity with protein engineering tools, such as PyMol, MolStar, and AlphaFold; experience with ML applications such as DiffDock, BoltzGen, etc. are a plus

• Backgrounds in neuroscience and/or sequencing technologies are a plus

• Excellent critical analysis skills and ability to assess data and research findings outside of Neurocrine for application to new scientific projects

• Advanced knowledge and demonstrated ability to work with a variety of laboratory equipment/tools

• Ability to work as part of teams

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Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

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The annual base salary we reasonably expect to pay is $88,000.00-$121,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.