Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.
What You Will Achieve
As a Principal Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute at the therapeutic area level and can represent the department on multidisciplinary teams.
You will perform qualitative and quantitative analyses of organic or inorganic compounds to determine chemical and physical properties during chemical syntheses and drug substance development process. You will be entrusted with setting objectives and planning resource requirements for your project team. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will undertake mentoring activities to guide team members.
It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.
How You Will Achieve It
For this Principal Scientist position, we are searching for a highly motivated scientist, with expertise with analytical control strategies and techniques in support of synthetic peptide chemistry development and manufacturing. You will collaborate with project teams and be responsible for the analytical strategies, test methods, specifications, and development studies key to synthetic peptide drug substance development. You will apply your expertise in separations and chromatography as well as other analytical methodologies (e.g. AAA, mass spectrometry, and NMR) to enable drug development.
Role Responsibilities
As a project analytical lead, the candidate will be responsible for developing analytical strategies in support of synthetic peptide drug substance during all development phases, including supporting manufacturing process development, assessment of starting materials, developing, validating and transferring analytical methods, designing stability studies to understand degradation mechanisms and for shelf-life assignments, developing impurity control strategies, and authoring associated regulatory documentation.
The candidate will perform lab work and will plan, direct, and review the lab work of other scientists in a matrix environment.
The role requires collaboration with internal colleagues and external partners to identify appropriate analytical approaches, including use of computational predictive tools, modeling software and data visualization tools where appropriate.
The candidate will critically review and interpret scientific data to derive clear conclusions and provide direction for future work and will communicate results and conclusions through various media including presentations and technical reports.
As a subject matter expert, the candidate will evaluate new approaches, instrumentation or analytical technologies and mentor other scientists.
The candidate will author relevant sections of the quality modules of regulatory submissions.
Basic Qualifications
Ph.D in Analytical Chemistry or related field, with 4+ years of R&D experience or MSc with 9+ years’ of R&D experience.
Demonstrated oral and written communication skills, including visualization of data, presentations and authoring technical articles.
Demonstrated ability to meet timelines and interact with multi-disciplinary teams.
Demonstrated ability to learn new techniques and solve complex analytical problems.
Attention to detail, strong organizational skills, and effective interpersonal and communication skills are required.
Proficient with a wide variety of software and information systems.
Preferred Qualifications
Experience with analytical aspects of synthetic peptide modalities, including hands on experience with advanced chromatographic analysis and method development along with fundamental understanding and working knowledge of various analytical techniques key to synthetic peptide drug substance development including MS, NMR, AAA, ICP-MS, GC, as well as higher order structure techniques (CD, MALS, etc.).
Understanding of impurity control strategies for synthetic peptides, including highlighting key risk factors associated with the synthetic scheme and purification processes.
Knowledge and experience with formal structural elucidation of peptide related impurities.
Demonstrated experience authoring and defending analytical strategies in regulatory submissions.
Demonstrated breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Sound knowledge of stage appropriate method development and related regulatory considerations.
PHYSICAL/MENTAL REQUIREMENTS
Ability to perform mathematical calculations and complex data analysis.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Some travel may be required. Ability to adhere to safe work practices and procedures.
Relocation support available.
Work Location Assignment: On Premise.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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