Post Doctoral Scientist Chemical Biology

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Post Doctoral Research Scientist in Chemical Biology position will focus on developing oral macrocyclic peptide efforts at Protomer Team in Eli Lilly. The successful candidate will use innovative display technologies (mRNA display, phage display, DNA-encoded libraries and one-bead-one-compound peptide libraries), molecular biology techniques and computational tools to develop high-throughput discovery tools for orally bioavailable macrocyclic peptides. The candidate will work in close collaboration with scientists across our company to develop and apply these technologies. This position allows for development of a comprehensive understanding of the R&D process and the essential role scientists play in creating solutions for Protomer team within Eli Lilly and Company.

Responsibilities:

• Contribute to projects in oral macrocycles, chemical biology or peptide frameworks combining aspect of molecule design and conjugation at the interface of small molecules and peptides.
• Work on display screening efforts from lead finding to lead optimization of oral macrocyclic peptide discovery projects
• Learn about and enhance the display platform technology efforts at Protomer to accelerate the lead finding and optimization process.
• Work collaboratively in the group to achieve a common goal but also provide independent perspective and scientific rationale and contribute to strategy and execution.  
• Be a good teammate and work effectively, responsibly and professionally with colleagues at Protomer and across Lilly.  

Basic Requirements:

• Ph.D. in Chemical Biology, Chemistry, Biochemistry, Biology, or related fields

• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

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Addition Skills/Preferences

• Experience with display technologies (mRNA display, ribosome display, phage display, DNA-encoded libraries and one-bead-one-compound peptide libraries)
• Experience with molecular biology techniques (PCR, Gel Electrophoresis, Western Blotting, etc)
• Knowledge of some of the latest developments in developing oral macrocyclic peptides or library-based selection approaches. 
• Proven track record of library-base screening or lead optimization efforts using display technologies/OBOC libraries/DEL technologies ideally in oral macrocycles
• Experience in bioinformatics, NGS analysis, peptide library designs.
• Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation.
• Experience in developing cell-based assays
• Familiarity with computational and structural efforts for hit identification and lead optimization in macrocyclic peptides. 
• Strong scientific communication skills
• Demonstrated record of scientific achievement
• Ability to work well independently and collaboratively

This position is not permanent. It is for a fixed duration of two years with the potential to extend to 3 years and for a maximum of up to 4 years. There will be an opportunity to apply for full-time positions after the duration of this role.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$58,000 - $123,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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