Pioneering Medicines: Principal Scientist / Associate Director , Non-Clinical Pharmacology

ABOUT PIONEERING MEDICINES

Pioneering Medicines, Flagship Pioneering’s in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship’s innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship’s bioplatform companies. Within Flagship’s Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners’ R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.

Position Summary:
We are seeking a Principal Scientist / Associate Director to serve as the nonclinical pharmacology lead across programs in inflammation, autoimmunity, and immuno-oncology. Reporting to the Head of Pharmacology, you will own the in vivo strategy from H2L through IND and partner seamlessly with Cell Biology, Translational Medicine, DMPK/QSP, Tox, and TechOps to generate robust, decision-quality data. You will work in a matrix environment guiding an internal in vivo team and managing an external network of CROs/consultants to design, execute, and interpret studies that define mechanism, dose/route/schedule, biomarkers, and combinations for Pioneering Medicines programs.

Responsibilities:

• Serve as Pharmacology Lead on cross-functional program teams; define the in vivo plan, milestones, budgets, and success criteria from target validation to IND.
• Design and execute disease & target-relevant efficacy models and PD/biomarker readouts across inflammation, autoimmunity, and IO (contributing hands on when necessary).
• Partner with DMPK/QSP to translate exposure–response into dose, route, schedule, and combination recommendations.
• Introduce and build new models/technologies as fit-for-purpose.
• Work closely with other FSP companies to develop research strategies and evaluate new programs.

Basic Qualifications:

• PhD, DVM, MS or equivalent inin vivo pharmacology or related discipline with a minimum of 5 years of experience within the Pharmaceutical/Biotechnology sector required.

• Extensive understanding of PK/PD assessments in models of disease and experience in designing ex vivo studies to assess PD and target engagement endpoints, is a must-have.
• Hands on experience with in vivo models of inflammation, autoimmunity and/or immunooncology preferred with PD endpoints including flow/IHC/cytokine assessments.
• Experience managing in vivo personnel and external CRO partners in a dynamic and fast-paced research environment.

Additional Qualifications and Skills:

• Experience working with standard modalities, such as small molecules, antibodies and peptides desired.
• Experience working in program teams in a matrix environment.
• Working knowledge of gene-based therapy approaches (gene regulation, RNA medicine, gene therapy, gene editing, and/or gene silencing) desirable but not required.
• Collaborative mindset and a willingness to work with different teams.
• Experience with Animal Care and Use protocol writing
• Excellent communication and writing skills.

LOCATION:  Cambridge, MA

ABOUT FLAGSHIP PIONEERING

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com. 

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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