ROLE SUMMARY – Quantitative Systems Pharmacologist (Associate Director)
Quantitative Systems Pharmacology (QSP) is a discipline that uses mechanistic mathematical models and disease platforms to enhance the robustness and quality of decision-making from exploratory research through clinical development. We are seeking a highly motivated individual to lead the development and application of QSP models for the in silico evaluation of novel targets and compounds, including preclinical and clinical study design and mechanistic interpretation of results. The successful candidate will be responsible for integrating and sharing data and knowledge in a highly stimulating, collaborative, and multi-disciplinary environment to develop a deeper understanding of physiological systems and disease mechanisms for the oncology therapeutic area.
ROLE RESPONSIBILITIES:
Build and utilize QSP models of biological, physiological, and/or pathophysiological processes to evaluate novel targets, pathways, and drug candidates
Identification of appropriate quantitative approaches for MIDD activities.
Work in close collaboration with biologists, clinicians, precision medicine scientists, clinical pharmacologists, pharmacometricians, QSP and nonclinical modelers, and other partner line colleagues to inform discovery and development programs and improve our understanding of disease mechanisms
·Serve as QSP modeling & simulation expert in, or leader of, multidisciplinary project teams to solve challenging problems in drug discovery and development; contribute to preclinical and clinical study designs and mechanistic interpretation of data
Develop and/or utilize state-of-the-art mathematical tools to gain insight into causal relationships between individual components of targets, pathways, and systems-level responses
·Analyze and interpret complex data sets in the context of disease mechanisms and pathways; develop a deep disease understanding and knowledge-base
BASIC QUALIFICATIONS:
Ph.D. in Applied Mathematics, Engineering, Physics, Pharmaceutical Sciences, or related disciplines with strong background in mathematical, statistical, and numerical methods with at least 1 year of experience
Experience in developing QSP and/or differential equation-based models of biological or physiological systems
PREFERRED QUALIFICATIONS:
Experience (~ 2 years+) in applying QSP approaches to drug discovery and development programs in the pharmaceutical industry
Experience in Oncology and Immuno-Oncology therapeutic areas
Growing ability to be a strategic contributor or leader in support of MIDD
Deep understanding of theory, principles, and statistical aspects of mathematical modeling and simulation, including numerical methods, parameter estimation/optimization, ordinary differential equations (ODEs), and how these can be applied in the development of complex models of biological pathways and systems
Computational fluency and extensive, hands-on experience with one or more modeling and simulation packages or programming languages (e.g., MATLAB, R, Julia, SimBiology, C/C++)
Creative and innovative scientist who is passionate about developing a deep understanding of disease and disease mechanisms and who has experience working closely with biologists, clinical and nonclinical modelers, and clinical colleagues
Self-directed, independent, and highly motivated researcher who excels in a collaborative, multi-disciplinary team environment
Excellent oral and written communication skills
Primary authorship on relevant publications in peer-reviewed scientific journals
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Additional Details:
Last date to apply is January 9, 2026
Work Location Assignment: This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week or more as needed.
Relocation assistance may be available based on business needs and/or eligibility.
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