Senior/Principal Scientist, DMPK

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

Company Description

Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design. Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! 

About the Role

We are seeking an innovative and collaborative Senior / Principal Scientist in Drug Metabolism and Pharmacokinetics (DMPK) to help shape the next generation of covalent small-molecule therapeutics for previously undruggable targets.  The successful candidate will have a proven track record of guiding small molecule drug discovery programs, including experience with both mono- and bi-functional modalities.  You will be a key architect in translating molecular design into human pharmacology — applying deep ADME/PK science and modeling insights to accelerate discovery, inform development candidate selection and support IND-enabling studies. 

We’re assembling the founding DMPK team — an extraordinary opportunity to operate at the intersection of chemoproteomics, quantum chemistry, and generative AI. You’ll work with the world’s most advanced chemoproteomics platform focused on undruggable targets and a deeply integrated AI-driven quantum chemistry engine to redefine what’s possible in modern drug discovery.

This role sits at the interface of chemistry, biology, formulation, pharmacology, toxicology and machine learning, working closely with program teams to drive decisions from first-in-class concept to IND.

Key Responsibilities

• Design and guide in-vitro and in-vivo ADME/PK studies to characterize absorption, distribution, metabolism, and excretion for small molecules (mono- and bi-functional modalities).
• Apply and advance modeling and simulation tools (PBPK, compartmental, and empirical) to interpret complex datasets and guide clinical pharmacology design.
• Integrate DMPK thinking early in discovery—connecting mechanistic data to compound design, structure–activity relationships, and developability.
• Shape translational PK-PD strategy, including in-vitro–in-vivo extrapolation, human dose projection, and species selection for efficacy and safety studies.
• Collaborate cross-functionally with medicinal chemistry, biology, pharmacology, toxicology and machine learning to inform compound prioritization and drive program progression.
• Author and critically review DMPK and modeling components of IND-enabling packages, investigator brochures, and regulatory filings.
• Leverage and manage CRO partners, ensuring scientific excellence, data integrity, and rapid execution of external studies. 
• Communicate insights with clarity and conviction—translating data into actionable hypotheses for multidisciplinary teams and senior leadership.
• Collaboratively implement a strong customer focus with the ability to have robust discussions with project leaders and other stakeholders to ensure that project, scientific and resource demands are aligned

Qualifications

• Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related discipline
  (or M.S. with ≥10 years of directly relevant biotech/pharma experience)
• 8–12+ years of experience in DMPK or ADME, ideally spanning discovery through IND enablement.
• Demonstrated impact on compound design and optimization through integration of DMPK science (mono- and bi-functional modalities).
• Hands-on experience with in-vitro ADME assays, in-vivo PK studies, in-vitro–in-vivo correlation building and generating human dose projections.
• Strong understanding of enzyme kinetics, transporters, and biotransformation mechanisms.
• Proficiency in PK-PD modeling, PBPK, and simulation approaches to support preclinical and clinical translation.
• Familiarity with regulatory expectations for ADME/PK characterization and drug–drug interaction assessment.
• Experience managing external collaborations and CRO partnerships.

You’ll Thrive Here If You

• Think from first principles 
• Value cross-disciplinary exploration, from chemistry to computation to translational biology.
• Approach others collaboratively.
• Are excited helping to build frameworks and platforms, not just running assays.
• Communicate complex data clearly, connecting mechanistic insight to program strategy.
• Enjoy fast-moving, hypothesis-driven environments.
• Are excited by the idea helping to build a first-in-class company that is redefining the future of drug discovery.

LOCATION: Cambridge, MA

ABOUT FLAGSHIP PIONEERING

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

 

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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The salary range for this role is $126,000 - $214,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Expedition Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Expedition Medicines's good faith estimate as of the date of publication and may be modified in the future.