Job Description
The Protein Sciences Department within the Discovery Biologics organization in South San Francisco is seeking an experienced Senior Scientist to join the Protein Characterization and Developability team. The team works integrated with other teams within Protein Sciences Department as well as Therapeutic Area discovery project teams and plays a pivotal role in early biologics discovery by engaging in high throughput biophysical screening, molecule optimization and developability assessments to enable selection of the best candidate molecule for further development. The successful candidate is expected to have deep knowledge and experience in protein chemistry and biophysical characterization of biologics using chromatographic methods such as SEC, HIC, RP, electrophoretic methods (CE-SDS, cIEF), light scattering methods (DLS/SLS) and other analytical methods such as nanoDSF, DSC, SINS, etc. The ideal candidate will have hands-on experience in characterization of biologics in different flavors – monoclonal antibodies (mAbs), bi-/multi-specifics, fusion proteins, antibody drug conjugates (ADCs), etc.
The successful candidate will primarily work on the bench and is expected to work independently and collaboratively to plan/design and execute experiments, develop/optimize methods, analyze and collate data and present at group, departmental, and team meetings. S/he is also expected to contribute for a smooth lab operation by actively addressing instrumentation issues, maintaining lab equipment, exploring/evaluating new technologies as well as adhering to laboratory safety practices.
The Senior Scientist will have the opportunity to work with a wide array of scientists and leaders from different departments and functional areas, engage with project teams, use the latest technologies as well as novel approaches, and make significant contributions towards our company biologics discovery pipeline.
Qualifications:
Education:
Required Experience and Skills:
Deep hands-on expertise in analytical characterization of proteins using a wide range of physicochemical characterization technologies.
Strong understanding of protein structure, biophysics, and analytical mindset to enable understanding of the relation between physicochemical properties and proteins structure/sequences
Previous experience with analytical characterization and developability assessment of biologics
Experience/Interest with high-throughput analytical characterization workflows
Strong analytical skills and attention to details
Demonstrated work on multiple projects and ability to meet aggressive timelines
Documentation of procedures, methods, data, and results in electronic laboratory notebooks
Team player with excellent interpersonal skills
Strong communication and presentation skills
Preferred Experience and Skills:
Analytical characterization of antibody drug conjugates (ADCs), bispecific antibodies, single chain Fvs (scFvs), VHHs and other biologics modalities
High throughput biophysical analysis of large number of candidates
Discovery project team membership and meaningful contribution to project advancements
#EligibleforERP
Required Skills:
Analytical Characterization, Antibody Drug Conjugates (ADC), Biochemistry, Biologics, Biophysics, Bispecific Antibodies, Physicochemical Characterization, Protein Characterization, Protein Chemistry, Protein StructurePreferred Skills:
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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
The salary range for this role is
$128,800.00 - $202,700.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
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Employee Status:
RegularRelocation:
Domestic/InternationalVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
Not ApplicableShift:
1st - DayValid Driving License:
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N/AJob Posting End Date:
11/11/2025*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.