At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.
Job Description
The Cell Culture Process Development group within Gilead is responsible for developing robust, scalable mammalian cell culture processes for Gilead’s very diverse early and late-stage biologics pipeline. We are seeking a highly motivated and innovative Postdoctoral Researcher to join the Cell Culture Process Development team at Gilead. This position will report into Cell Culture Process Development within the Biologics Pivotal & Commercial Organization.
The Postdoctoral Researcher will be a member of the Cell Culture Media Strategy team and contribute to the optimization of cell culture media for mammalian cell lines expressing a diverse range of biologics including monoclonal antibodies, multi-specific antibodies, and other complex/novel modalities. This is a unique opportunity to work at the intersection of cell biology, biochemistry, and bioprocess engineering and contribute to cutting-edge research to enhance cell growth, productivity, and product quality for manufacturing of biologics drugs.
The successful candidate is expected to work collaboratively with others in the team and independently when needed to implement best laboratory practices and lead the execution of complex experiments. They should demonstrate scientific curiosity, outstanding communication skills, a commitment to continuous learning, and contribute to organizational knowledge while fostering inclusive teamwork.
Key Responsibilities:
Design experiments and perform hands-on buffer/media preparation and cell culture operations in shake flasks, ambr15, ambr250, bench-scale bioreactors, and novel cell culture platforms
Lead aspects of optimizing chemically defined cell culture media to improve productivity and modulate product quality for fed-batch and perfusion processes
Apply statistical and computational tools (e.g., DoE, multivariate analysis) to interpret experimental data and guide media formulation strategies
Elucidate mechanistic understanding of key factors and associated metabolic pathways relating to cell culture medium and process development using advanced bio-analytical techniques such as bioassays, proteomics, and metabolomics
Participate and work cross-functionally within and outside of biologics technical development to achieve common goals
Prepare technical reports, protocols, presentations, and manuscripts for internal and external dissemination
Occasional weekend work may be required to support cell culture operations
Maintain accurate and detailed laboratory records in compliance with institutional and regulatory standards
Adhere to department budget and all training, compliance and safety requirements. Support general laboratory upkeep.
Basic Qualifications/Skills/Experience:
Ph.D. in a relevant scientific discipline (Biology, Biochemistry, Bioengineering, Chemical Engineering, Biomolecular Engineering) with 0-2 years of relevant experience OR expected PhD graduation within 6 months from date of application
Motivated self-starter with organizational and problem-solving skills. Excellent verbal communication, oral presentation, and scientific writing skills
Demonstrates technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design
Passion for inclusion: knowing the business value of diverse teams, modelling inclusion, and embedding the value of diversity in the way they work
Preferred Qualifications/Skills/Experience:
Hands-on laboratory operations experience in CHO cell culture including shake flask, high-throughput bioreactor (e.g., ambr15, ambr250), bench scale bioreactor in parallel operation
Experience with serum-free, chemically defined media optimization
Solid understanding of CHO cell metabolism, bioprocessing, and media formulation principles
Experience with tools for metabolic pathway analyses and bio-analytical techniques such as proteomics, metabolomics, and bioassays for gene expression analysis to guide media optimization
Experience with kinetic modeling and computational tools (e.g., Python, R, MATLAB)
Experience in statistics, design-of-experiments, and data analysis (e.g. JMP, Spotfire)
Proven track record of external presentations and/or publications in peer-reviewed journals
For additional benefits information, visit:
https://www.gilead.com/careers/compensation-benefits-and-wellbeing
* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.
Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.
For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.
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