AstraZeneca

Director, Cell Therapy Discovery

Shanghai Jing'An Office Full time

Typical Accountabilities

Strategic Planning & Execution:
Develop long-term departmental goals and ensure alignment with the company’s overall R&D strategy. Lead and plan the strategic direction for product research and development. Support the Head of R&D in establishing management systems, development schemes, and operational processes.

Product Development Guidance:
Provide strategic and constructive input on R&D product planning. Offer insights and recommendations to senior management for decision-making. Support teams in troubleshooting and ensure timely delivery of all projects within defined timelines and quality standards.

Budget & Plan Management:
Develop and manage departmental R&D plans and budgets. Oversee the implementation and execution of R&D activities within the approved financial framework. Ensure effective cost control and on-time, on-budget completion of projects.

Technology Innovation & Project Management:
Lead the team in designing CAR-T products, developing new technologies, and filing related technical patents. Supervise project implementation within the department to ensure timely and high-quality delivery.

Cross-functional Collaboration:
Collaborate closely with Operations, Clinical, Regulatory Affairs, and Process Development teams to support project submission and product registration. Ensure smooth execution of company objectives and timely completion of R&D milestones.

Academic Research & Reporting:
Lead the company’s academic research initiatives and external R&D progress reports. Organize manuscript submissions to high-impact international journals and presentations at global conferences. Enhance the company’s academic influence and promote international recognition of technological achievements.

Resource Integration & Partnership:
Coordinate internal and external resources within the company and the broader group to meet R&D and business development needs. Build and maintain collaborations with external partners, research institutions, and regulatory authorities to drive project advancement.

Leadership & Motivation:
Lead, inspire, and empower the R&D team to achieve high performance and innovation excellence.

Other Responsibilities:
Perform other duties as assigned by senior management.

Academic / Professional Qualification

Ph.D. in Molecular Biology, Cell Biology, Immunology, or related biomedical disciplines with 8–10 years of relevant R&D experience in the biopharmaceutical industry;
or Master’s degree with 12+ years of related R&D experience.

In-depth expertise in T-cell culture and engineering, molecular biology techniques, flow cytometry, and cell purification.
Strong proficiency in CAR-T product design, experimental design and execution, plasmid construction and purification, viral vector production and purification, T-cell transduction and gene editing, peripheral blood and T-cell isolation (MACS sorting), ELISA, proliferation assays, PCR/qPCR, multicolor flow cytometry, and tumor cell cytotoxicity assays in vitro and in vivo.

Minimum 3 years of R&D project and team management experience.

Technical / Skills Requirements

Excellent strategic thinking and innovation mindset

Strong global vision and ability to operate in an international environment

Demonstrated excellence-driven and results-oriented attitude

Profound insight into relevant scientific research areas

Commitment to lifelong learning and continuous professional growth

High self-motivation and initiative

Strong cross-cultural adaptability and collaborative spirit

Proven project management and team leadership capabilities

Exceptional communication, coordination, and resource management skills

Fluent in English, with strong cross-cultural communication and presentation abilities

Date Posted

12-11月-2025

Closing Date

13-11月-2025

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.